BioCentury
ARTICLE | Distillery Therapeutics

Therapeutics: Muscarinic acetylcholine receptor M1 (CHRM1; HM1); CHRM4 (HM4)

September 22, 2016 7:00 AM UTC

Mouse studies suggest antagonizing CHRM1 or CHRM4 could help treat PD. In a mouse model of PD, intrastriatal injection of the CHRM1 antagonist telenzepine or the CHRM4 antagonist tropicamide decreased sensorimotor and motor deficits compared with vehicle. Next steps could include identifying and testing dual CHRM1/CHRM4 antagonists in models of PD.

The generic telenzepine is marketed to treat peptic ulcers...