BioCentury
ARTICLE | Distillery Therapeutics

Therapeutics: Kelch-like ECH-associated protein 1 (KEAP1); nuclear factor (erythroid-derived 2)-like 2 (NFE2L2; NRF2)

September 24, 2015 7:00 AM UTC

In vitro and mouse studies suggest inhibiting the KEAP1-NFE2L2 interaction could help treat inflammation. Disassociation of the KEAP1-NFE2L2 complex activates NFE2L2-mediated antioxidant responses. Ch...