Therapeutics: CTLA-4 (CD152)

Mouse studies suggest combining anti-CTLA-4 antibodies and Vidaza azacitidine could help treat melanoma. In a mouse model of melanoma, Vidaza plus an anti-CTLA-4 antibody decreased tumor growth compared with either agent alone. Next steps could include clinical testing of anti-CTLA-4 antibodies in combination with Vidaza in melanoma patients...