BioCentury
ARTICLE | Distillery Therapeutics

Therapeutics: Cyclooxygenase-2 (COX-2); 5-lipoxygenase (ALOX5; 5-LO)

August 27, 2015 7:00 AM UTC

In vitro and mouse studies suggest an inhibitor of COX-2 and ALOX5 could treat pain and inflammation. Chemical synthesis of barbituric acid analogs followed by testing in COX-2 and ALOX5 assays identi...