BioCentury
ARTICLE | Distillery Therapeutics

Therapeutics: Bruton's tyrosine kinase (Btk)

July 16, 2015 7:00 AM UTC

Mouse studies suggest ibrutinib and other Btk inhibitors could help treat stroke. In a mouse model of ischemic stroke, ibrutinib decreased infarct size and neurological deficits compared with vehicle. Also in the mouse model, ibrutinib decreased brain levels of the pro-inflammatory cytokine interleukin-1 (IL-1) β. Next steps could include testing Btk inhibitors in other models of stroke...