Therapeutics: Monoacylglycerol O-acyltransferase 2 (MOGAT2; MGAT2)

Mouse studies suggest inhibiting MOGAT2 could help treat hyperglyceridemia and other metabolic diseases. Optimization of an N-phenylindoline-5-sulfonamide-based MOGAT2 inhibitor (IC50 = 130 nM) result...