BioCentury
ARTICLE | Distillery Therapeutics

Therapeutics: Phosphodiesterase-4 (PDE-4); sonic hedgehog (SHH)

April 16, 2015 7:00 AM UTC

In vitro and zebrafish studies suggest PDE-4 inhibitors could help treat cancers that involve overactive hedgehog signaling. A chemical screen in zebra embryos and in vitro testing of the lead hit, eg...