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Infectious disease


Plasmodium falciparum apical membrane antigen 1 (ama1); P. falciparum rhoptry neck protein 2 (Pfron2)

In vitro and mouse studies suggest vaccination with a P. falciparum ama1-Pfron2 fusion peptide could help prevent malaria. In mice, immunization with the P. yoelii ama1-Pfron2 fusion peptide protected all animals from lethal P. yoelii challenge, whereas immunization with either peptide alone did not. In a growth inhibition assay, IgG from rats immunized with the P. falciparum ama1-Pfron2 fusion peptide decreased P. falciparum merozoite invasion compared with IgG from ama1-immunized animals. Next steps include assessing the safety of the vaccine candidate in humans.

SciBX 7(29); doi:10.1038/scibx.2014.866
Published online July 31, 2014

Patent application filed; available for licensing

Srinivasan, P. et al. Proc. Natl. Acad. Sci. USA; published online June 23, 2014;
Contact: Louis H. Miller, National Institute of Allergy and Infectious Diseases, Rockville, Md.

Contact: Prakash Srinivasan, same affiliation as above