Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Hematology

Hematology

Purinergic receptor P2Y
G protein-coupled 14
(P2Y14)

Mouse studies suggest agonizing P2Y14 could help protect hematopoietic cells against radiation-induced damage. In mice, knocking out P2y14 did not affect animals under normal conditions but did increase senescence in hematopoietic stem and progenitor cells (HSPCs) after ionizing radiation. In mice, knocking out P2y14 led to increased levels of reactive oxygen species (ROS) following radiation exposure compared with no alteration. In the P2y14 knockout mice, an ROS scavenger decreased radiation-induced senescence in HSPCs compared with no treatment. Next steps include testing the effects of increasing P2Y14 signaling during radiation exposure.

SciBX 7(29); doi:10.1038/scibx.2014.864
Published online July 31, 2014

Unpatented; licensing status not applicable

Cho, J. et al. J. Clin. Invest.; published online June 17, 2014;
doi:10.1172/JCI61636
Contact: Byeong Chel Lee, University of Pittsburgh Cancer Institute, Pittsburgh, Pa.
e-mail:
leeb4@upmc.edu

Contact: David T. Scadden, Massachusetts General Hospital, Boston, Mass.
e-mail:
david_scadden@harvard.edu