Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Endocrine/metabolic disease

Obesity

Not applicable

Mouse studies suggest gut microbiota that express N-acylphosphatidylethanolamines (NAPEs) could help treat or prevent obesity. In mice fed a high-fat diet, drinking water containing Escherichia coli engineered to express NAPE decreased food intake, adiposity, insulin resistance and hepatosteatosis compared with drinking water containing control bacteria or water without added bacteria. In a polygenic mouse model of obesity, NAPE-expressing E. coli decreased weight gain compared with control bacteria or vehicle. Next steps could include evaluating the safety of the bacteria.

SciBX 7(29); doi:10.1038/scibx.2014.863
Published online July 31, 2014

Patent and licensing status unavailable

Chen, Z. et al. J. Clin. Invest.; published online June 24, 2014;
doi:10.1172/JCI72517
Contact: Sean S. Davies, Vanderbilt University, Nashville, Tenn.
e-mail:
sean.davies@vanderbilt.edu