Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Cancer

Glycocalyx

Studies in patient samples and cell culture suggest decreasing the extracellular glycoprotein and glycan polymeric layer called the glycocalyx could help treat cancer and prevent metastasis. Circulating tumor cells isolated from patients with aggressive breast cancers showed high expression of bulky glycoproteins and bulk-adding glycosyltransferases. Nonmalignant mammary epithelial cells modified to produce a bulky glycocalyx showed increased growth and survival on tumor microenvironment-mimicking hydrogel substrates compared with controls that had normal glycocalyx. Ongoing work includes studies to further assess the relevance of the glycocalyx to tumor metastasis, receptor structure and function, and the signaling, recycling and endocytosis of growth factor receptors.

SciBX 7(29); doi:10.1038/scibx.2014.859
Published online July 31, 2014

Patent and licensing status undisclosed

Paszek, M.J. et al. Nature; published online June 25, 2014;
doi:10.1038/nature13535
Contact: Valerie M. Weaver, University of California, San Francisco, Calif.
e-mail:
valerie.weaver@ucsfmedctr.org