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Breast cancer

Estrogen receptor-b

Studies in patient samples and mice suggest promoting phosphorylation of tyrosine 36 (Y36) on estrogen receptor-b could help treat breast cancer. In mouse xenograft models of breast cancer, expression of estrogen receptor-b Y36 blocked antitumor activity of the receptor. In tissue samples from patients with breast cancer, high levels of phosphorylated estrogen receptor-b Y36 were associated with improved disease-free and overall survival. Next steps include exploring the value of Y36 phosphorylation of estrogen receptor-b as a prognostic marker and targeting proteins involved in this pathway.

SciBX 7(29); doi:10.1038/scibx.2014.856
Published online July 31, 2014

Patent application filed; available for licensing from The University of Texas Health Science Center at San Antonio's Office of Technology Transfer and Commercialization

Yuan, B. et al. J. Clin. Invest.; published online June 24, 2014;
Contact: Rong Li, The University of Texas Health Science Center at San Antonio, San Antonio, Texas

Contact: Qinong Ye, Beijing Institute of Biotechnology, Beijing, China