Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Endocrine/metabolic disease

Obesity

Adenosine A2B receptor (ADORA2B); kruppel-like factor 4 (KLF4; EZF)

Mouse and cell culture studies suggest activating ADORA2B could help treat obesity. In cultured stromal vascular cells, an ADORA2B agonist inhibited lipid accumulation, prevented differentiation into adipocytes and increased KLF4 signaling compared with vehicle. In mice, Adora2b siRNA decreased Klf4 expression and increased expression of adipose-selective markers compared with scrambled siRNA. Next steps could include evaluating ADORA2B-selective agonists in animal models of obesity.

SciBX 7(28); doi:10.1038/scibx.2014.826
Published online July 24, 2014

Patent and licensing status unavailable

Eisenstein, A. et al. J. Biol. Chem.; published online June 13, 2014;
doi:10.1074/jbc.M114.566406
Contact: Katya Ravid, Boston University School of Medicine, Boston, Mass.
e-mail:

kravid@bu.edu