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Breast cancer

RAS oncogene family member RAB22A

In vitro and mouse studies suggest inhibiting RAB22A could help suppress breast cancer metastasis. In multiple cultured human breast cancer cell lines, hypoxia increased shedding of microvesicles compared with normoxia via hypoxia-inducible factor 1 (HIF1)-dependent RAB22A transcription. In in vitro invasion or in vivo metastasis assays in mice, microvesicles from RAB22A-depleted human breast cancer cell lines exposed to hypoxia had decreased ability to induce invasion in Matrigel and metastasis to lungs compared with microvesicles from cells expressing normal levels of RAB22A. Next steps could include identifying strategies to target RAB22A-producing, metastasis-promoting microvesicles.

SciBX 7(28); doi:10.1038/scibx.2014.820
Published online July 24, 2014

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Wang, T. et al. Proc. Natl. Acad. Sci. USA; published online June 17, 2014;
Contact: Gregg L. Semenza, The Johns Hopkins University School of Medicine, Baltimore, Md.