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Autoimmune disease

Inflammatory bowel disease (IBD)


Studies in human samples and mice suggest antagonizing IL-9 could help treat IBD. In samples from patients with ulcerative colitis (UC), IL-9 expression was higher than that in samples from healthy controls and was associated with active disease. In a mouse model of UC, Il-9 knockout decreased weight loss, proinflammatory cytokine expression and mucosal inflammation compared with no alteration. In the mouse model, an anti-IL-9 antibody decreased body weight loss and colitis severity compared with an isotype control antibody. Next steps include assessing expression of IL-9 in patients who are refractive to anti-tumor necrosis factor (TNF) therapy and testing the effects of IL-9 on mucosal healing.

SciBX 7(27); doi:10.1038/scibx.2014.786
Published online July 17, 2014

Unpatented; licensing status not applicable

Gerlach, K. et al. Nat. Immunol.; published online June 8, 2014;
Contact: Markus F. Neurath, University of Erlangen-Nuremberg, Erlangen, Germany