Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Inflammation

Inflammation

Inducible nitric oxide synthase 2 (NOS2; iNOS); JAK kinase (JAK); signal transducer and activator of transcription 1 (STAT1)

Cell culture studies have identified a saccharin derivative that could be useful for treating interferon (IFN)-mediated inflammation. In a murine macrophage cell line, the lead derivative inhibited lipopolysaccharide (LPS)-induced production of proinflammatory factors with an IC50 value of 9.61 mM. The compound decreased LPS-induced production of proinflammatory factors by downregulating iNOS to inhibit IFN-mediated activation of the JAK/STAT1 pathway. Next steps include identifying a specific disease indication to target with the identified inhibitors.

SciBX 7(25); doi:10.1038/scibx.2014.743
Published online June 26, 2014

Unpatented; licensing details available from the University of Colorado Technology Transfer Office
Contact: Darcey Miller, University of Colorado, Denver, Colo.
e-mail:

darcey.miller@cu.edu

Csakai, A. et al. J. Med. Chem.; published online May 24, 2014;
doi:10.1021/jm500409k
Contact: Hang Yin, University of Colorado at Boulder, Boulder, Colo.
e-mail:

hubert.yin@colorado.edu