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Infectious disease


Plasmodium falciparum schizont egress antigen-1 (Pfsea-1)

Mouse and cell culture studies suggest inhibiting Pfsea-1 could help protect against malaria infection. In cocultures of red blood cells (RBCs) and three strains of P. falciparum, anti-Pfsea-1 antibodies decreased parasite growth by 58%-74% compared with control sera. In in vitro assays, an anti-Pfsea-1 antibody prevented P. falciparum schizonts from leaving infected RBCs. In mice, vaccination with recombinant sea-1 from P. berghei plus an adjuvant stimulated an immune response against the antigen and resulted in increased survival following a P. berghei challenge compared with vaccination using adjuvant alone. Next steps include trials in nonhuman primates and then a Phase I trial.

SciBX 7(25); doi:10.1038/scibx.2014.742
Published online June 26, 2014

Patent pending; available for licensing

Raj, D.K. et al. Science; published online May 23, 2014;
Contact: Jonathan D. Kurtis, Brown University, Providence, R.I.