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Dental disease

Dental tissue repair

Transforming growth factor-b1 (TGFB1)

Mouse and cell culture studies suggest photoactivation of latent TGFB1 could help regenerate teeth. In a rat pulp-dentin healing model, low-power laser treatment increased tertiary dentin volumes compared with no treatment. Pharmacological or genetic inhibition of Tgfb1 signaling prevented the response, suggesting the treatment effect results from the release of latent Tgfb1. In cultured mouse dental stem cells treated with a low-power laser, pharmacological inhibition of Tgfb1-releasing reactive oxygen species or transforming growth factor-b receptor 1 (Tgfbr1; Alk5) blocked the cells from differentiating into dentin-forming odontoblasts. Next steps include improving the approach to generate more organized dentin and determining an optimal treatment regimen for human studies.

SciBX 7(25); doi:10.1038/scibx.2014.736
Published online June 26, 2014

Patent application filed; available for licensing

Arany, P.R. et al. Sci. Transl. Med.; published online May 28, 2014;
Contact: David J. Mooney, Harvard School of Engineering and Applied Sciences, Cambridge, Mass.