Thursday, June 19, 2014
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Hypoxia-inducible factor prolyl hydroxylase 1 (EGLN2;
Mouse studies suggest
pan-PHD inhibitors could help prevent damage to the GI tract and death
resulting from acute radiation exposure. In irradiated mice, knockout of Phd1,
Phd2 and Phd3 in GI tissues or pretreatment with a pan-PHD
inhibitor decreased markers of GI toxicity and increased survival compared
with no knockout or with vehicle pretreatment. In wild-type mice, the pan-PHD
inhibitor improved survival in animals treated after total abdominal
irradiation but failed to do so in animals treated after total body
irradiation. Ongoing work includes testing additional PHD inhibitors in mice
before and after radiation exposure.
Pharma Inc. and AstraZeneca
plc have the small molecule PHD inhibitor roxadustat
in Phase III testing to treat anemia in patients with chronic kidney disease
(CKD) and end-stage renal disease (ESRD).
FibroGen and Astellas have the small molecule PHD inhibitor FG-2216
in Phase II testing to treat anemia in patients with CKD.
Therapeutics Inc. has the oral PHD inhibitor AKB-6548
in Phase IIb testing to treat anemia in patients with CKD.
Published online June 19, 2014
Patent application filed;
available for licensing
Taniguchi, C.M. et al.
Sci. Transl. Med.;
published online May 14, 2014;
Contact: Amato J. Giaccia, Stanford University, Stanford, Calif.
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