Thursday, June 19, 2014
Publication and contact
Hypoxia-inducible factor prolyl hydroxylase 1 (EGLN2;
Mouse studies suggest
pan-PHD inhibitors could help prevent damage to the GI tract and death
resulting from acute radiation exposure. In irradiated mice, knockout of Phd1,
Phd2 and Phd3 in GI tissues or pretreatment with a pan-PHD
inhibitor decreased markers of GI toxicity and increased survival compared
with no knockout or with vehicle pretreatment. In wild-type mice, the pan-PHD
inhibitor improved survival in animals treated after total abdominal
irradiation but failed to do so in animals treated after total body
irradiation. Ongoing work includes testing additional PHD inhibitors in mice
before and after radiation exposure.
Pharma Inc. and AstraZeneca
plc have the small molecule PHD inhibitor roxadustat
in Phase III testing to treat anemia in patients with chronic kidney disease
(CKD) and end-stage renal disease (ESRD).
FibroGen and Astellas have the small molecule PHD inhibitor FG-2216
in Phase II testing to treat anemia in patients with CKD.
Therapeutics Inc. has the oral PHD inhibitor AKB-6548
in Phase IIb testing to treat anemia in patients with CKD.
Published online June 19, 2014
Patent application filed;
available for licensing
Taniguchi, C.M. et al.
Sci. Transl. Med.;
published online May 14, 2014;
Contact: Amato J. Giaccia, Stanford University, Stanford, Calif.
All contents Copyright © 1993-2015 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]