Thursday, June 19, 2014
Publication and contact
Alzheimer's disease (AD)
Serotonin (5-HT) transporter (SLC6A4;
Mouse and human studies
suggest selective serotonin reuptake inhibitors (SSRIs) could help prevent
AD. In three-month-old mice expressing human amyloid precursor
and free of b-amyloid (Ab)-related
pathology, the SSRI Celexa
caused dose-dependent decreases in Ab levels in brain and
interstitial fluid within 24 hours. In a cohort of 23 healthy human subjects
between ages 18 and 50, citalopram decreased Ab levels in
cerebrospinal fluid by 37% compared with placebo. Next steps could include
developing strategies to identify human subjects with high baseline levels of
Ab that could benefit from SSRIs.
Citalopram is marketed by H.
Lundbeck A/S and Forest
Laboratories Inc. to treat depression.
Published online June 19, 2014
Patent and licensing status
Sheline, Y.I. et al.
Sci. Transl. Med.;
published online May 14, 2014;
Contact: Yvette I. Sheline, University of Pennsylvania, Philadelphia,
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