Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Neurology

Alzheimer's disease (AD)

a-Melanocyte stimulating hormone (a-MSH); b-amyloid (Ab)

Mouse studies suggest a-MSH could help treat AD. In mice with established Ab pathology and behavioral deficits, i.p. injection of a-MSH prevented the development of spatial memory deficits, whereas vehicle did not. Next steps could include testing a-MSH in additional models of AD and at different stages of the disease.
Clinuvel Pharmaceuticals Ltd.'s CUV9900, an a-MSH analog, is in preclinical development for dermatology indications.

SciBX 7(24); doi:10.1038/scibx.2014.716
Published online June 19, 2014

Patent and licensing status unavailable

Ma, K. & McLaurin, J. J. Neurosci.;
published online May 14, 2014;
doi:10.1523/JNEUROSCI.5075-13.2014
Contact: JoAnne McLaurin, University of Toronto, Toronto, Ontario, Canada
e-mail:
j.mclaurin@utoronto.ca