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Endothelin 1 (EDN1; ET1); endothelin A receptor; endothelin converting enzyme 1 (ECE1)

Mouse and human studies suggest inhibiting endothelin A receptor could help treat itch. In skin samples from mice with pruritic chronic dermatitis and patients with the pruritic skin disorder prurigo nodularis, endothelin A receptor, ET1 and ECE1 were expressed and co-localized in peripheral nerves, suggesting the endothelin A signaling pathway is involved in itch. In a mouse model of chronic itch, an endothelin A receptor inhibitor decreased scratching behavior and chronic dermatitis compared with no treatment. Next steps include further investigating the role of the ET1 and endothelin A receptor pathway in models of histamine-independent itch.

SciBX 7(24); doi:10.1038/scibx.2014.709
Published online June 19, 2014

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Kido-Nakahara, M. et al. J. Clin. Invest.; published online May 8, 2014;
Contact: Martin Steinhoff, University College Dublin, Dublin, Ireland