Thursday, June 19, 2014
Publication and contact
Tumor necrosis factor receptor superfamily member
activator of NF-kB ligand
In vitro and mouse studies suggest RANKL could help reduce
ischemic brain damage following stroke. OPG, which binds RANKL and inhibits
signaling through RANK
is upregulated following stroke. In mice, Opg knockout or
intracerebroventricular injection of Rankl decreased infarct volume and
cerebral edema following middle cerebral artery occlusion compared with no
knockout or injection of a control protein. In the mice with cerebral artery
occlusion, a Rankl-neutralizing antibody increased infarct volume compared
with a control protein. In neurons cocultured with microglia, RANKL inhibited
inflammatory cytokines and neuronal cell death. Next steps include assessing
the effects of systemic RANKL delivery on ischemic injury.
Published online June 19, 2014
Patent application filed;
available for licensing
Shimamura, M. et al.
Proc. Natl. Acad. Sci. USA; published online May 20, 2014;
Contact: Ryuichi Morishita, United Graduate School of Child
Development, Osaka, Japan
All contents Copyright © 1993-2017 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]