Thursday, June 19, 2014
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IL-17; IL-17 receptor (IL17R;
Human sample and mouse
studies suggest inhibiting IL-17 signaling could help treat pancreatic
cancer. Chronic pancreatitis accelerates pancreatic cancer, and chronic
inflammation can induce pancreatic intraepithelial neoplasias (PanINs). In
human tissue arrays, IL17R expression was greater in pancreatic lesions,
including PanINs, than normal acinar tissue. In a mouse model of inducible
pancreatitis that progresses to PanIN, Il-17 was expressed in Cd4+ T cells, and depletion of Cd4+ T cells delayed progression. In the mice, a
cocktail of anti-IL17R and anti-IL-17 mAbs decreased PanINs on the pancreas
surface and the number of advanced PanINs compared with saline. Next steps
include neutralizing IL-17 signaling in more advanced metastatic disease
models and identifying patients that would benefit from IL-17 inhibition.
plc and Kyowa
Hakko Kirin Co. Ltd. have brodalumab,
a humanized mAb against IL17R, in Phase III or earlier testing to treat
autoimmune and inflammatory indications.
At least seven companies have antibodies against IL-17 in Phase II or earlier
testing to treat various indications.
Published online June 19, 2014
status not applicable
McAllister, F. et al.
published online May 12, 2014;
Contact: Steven D. Leach, The Johns Hopkins University, Baltimore,
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