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Breast cancer

Granulocyte macrophage colony-stimulating factor (GM-CSF; CSF2); chemokine CC motif ligand 18 (CCL18); phosphatidylinositol transfer protein membrane associated family member 3 (PITPNM3)

Mouse and human sample studies suggest blocking secreted GM-CSF or CCL18 could help prevent breast cancer metastasis. In a humanized mouse model of metastatic breast cancer, a neutralizing antibody against tumor cell-secreted GM-CSF reduced numbers of tumor-associated macrophages (TAMs), inhibited metastasis and prolonged metastasis-free survival. In the same model, a neutralizing antibody against TAM-secreted CCL18 reduced epithelial-to-mesenchymal transition of tumor cells, inhibited metastasis and prolonged metastasis-free survival. In human breast cancer samples or patient data collections, high GM-CSF expression correlated with elevated numbers of stromal CCL18+ cells or higher tumor grade and poor prognosis. Next steps include developing antibodies and identifying small molecules able to inhibit the CCL18 receptor PITPNM3.

SciBX 7(24); doi:10.1038/scibx.2014.698
Published online June 19, 2014

Patent application filed; licensing status undisclosed

Su, S. et al. Cancer Cell;
published online May 12, 2014;
Contact: Erwei Song, Sun Yat-sen University, Guangzhou, China