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Autoimmune disease

Multiple sclerosis (MS)

Prostaglandin E2 receptor EP2 subtype (prostanoid EP2 receptor; PTGER2); RAR-related orphan receptor C (RORC; RORg)

Studies in human samples and mice suggest inhibiting PTGER2 could help treat MS. In T helper type 17 (Th17) cells from healthy subjects, overexpression of PTGER2 or siRNA knockdown of the PTGER2 inhibitor RORC induced a pathogenic inflammatory phenotype. In Th17 cells from patients with MS, PTGER2 expression was higher than that in cells from healthy subjects. Next steps could include testing PTGER2 inhibitors in models of MS.

SciBX 7(24); doi:10.1038/scibx.2014.696
Published online June 19, 2014

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Kofler, D.M. et al. J. Clin. Invest.;
published online May 8, 2014;
Contact: David A. Hafler, Yale School of Medicine, New Haven, Conn.
Contact: David M. Kofler, same affiliation as above