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Stroke; nerve damage

Casein kinase 1 (CSNK1; CKI); RE1-silencing transcription factor (REST; NRSF)

In vitro and rat studies suggest activating CKI could help protect against stroke-associated neuronal death. In rats, global ischemia decreased Cki expression, increased Rest expression and increased death of CA1 hippocampal neurons compared with no ischemia. In rats, intracerebroventricular delivery of the CK1 activator pyrvinium decreased ischemia-induced Rest expression and death of CA1 neurons compared with no treatment. Next steps could include developing selective CKI activators and evaluating them in stroke models.

SciBX 7(19); doi:10.1038/scibx.2014.565
Published online May 15, 2014

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Kaneko, N. et al. J. Neurosci.; published online April 23, 2014;
Contact: R. Suzanne Zukin, Albert Einstein College of Medicine of Yeshiva University, New York, N.Y.