Thursday, May 15, 2014
Publication and contact
DNA-damage-inducible transcript 4 (DDIT4;
Rodent and human studies
suggest inhibiting REDD1 could help treat major depressive disorder (MDD). In
postmortem human prefrontal cortex samples from patients with MDD, mRNA
expression of the mammalian
target of rapamycin complex 1 (mTORC1)
inhibitor REDD1 was increased compared with that in samples from individuals
without MDD. Redd1 knockout mice showed resistance to chronic stress-induced
behaviors and decreases in mTORC1 signaling and the number and function of
spine synapses compared with wild-type mice. In rats, injection of a REDD1-expressing
viral vector into the prefrontal cortex induced behaviors and neuronal
atrophy similar to those caused by chronic stress. Next steps include
screening for compounds that disrupt the effect of REDD1.
RiboQuark Pharmaceutical Technology Co. Ltd. and Pfizer
Inc. have PF-655,
an siRNA targeting REDD1, in Phase II testing to treat diabetic macular edema
(DME) and wet age-related macular degeneration (AMD).
Published online May 15, 2014
Unpatented; unavailable for
Ota, K.T. et al. Nat.
Med.; published online April 13, 2014;
Contact: Ronald S. Duman, Yale School of Medicine, New
All contents Copyright © 1993-2016 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]