Licensing status

Publication and contact information

Cardiovascular disease

Ischemia/reperfusion injury

Neuron-derived neurotrophic factor (NDNF); endothelial cell nitric oxide synthase 3 (NOS3; eNOS); protein kinase B (PKB; PKBA; AKT; AKT1)

Mouse studies suggest NDNF could be used to stimulate revascularization in ischemic vascular disease. In a mouse model of hindlimb ischemia, Ndnf expression was increased. siRNA against Ndnf impaired blood flow recovery and decreased eNos and Akt activation compared with control siRNA. In the same model, pretreatment with an intramuscular injection of an adenoviral vector expressing Ndnf led to eNos and Akt activation and increased blood flow recovery compared with pretreatment using an adenoviral vector expressing a control protein. Next steps include examining the effect of Ndnf on ischemic peripheral artery disease in diabetic mice.

SciBX 7(19); doi:10.1038/scibx.2014.558
Published online May 15, 2014

Unpatented; licensing status not applicable

Ohashi, K. et al. J. Biol. Chem.; published online April 6, 2014;
Contact: Noriyuki Ouchi, Nagoya University Graduate School of Medicine, Nagoya, Japan