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Infectious disease

Influenza virus

Microsomal prostaglandin E synthease-1 (PTGES; mPGES-1)

Mouse studies suggest inhibiting PTGES could help treat influenza A virus infection. In mice infected with influenza A, Ptges knockout increased macrophage, monocyte and dendritic cell numbers in the lungs and increased T cell numbers in lungs and lymph nodes compared with no alteration. In mice lacking T and B cells, adoptive transfer of Ptges-deficient, influenza-infected macrophages led to a lower viral load and a stronger antiviral interferon response than adoptive transfer of infected wild-type macrophages. In wild-type mice, an inhibitor of PTGES decreased viral load and increased survival compared with saline. Next steps include testing a selective PTGES inhibitor in humans.

SciBX 7(18); doi:10.1038/scibx.2014.529
Published online May 8, 2014

Findings unpatented; licensing status not applicable

Coulombe, F. et al. Immunity; published online April 10, 2014;
Contact: Maziar Divangahi, McGill University, Montreal, Quebec, Canada