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Endocrine/metabolic disease

Diabetes; obesity

Nicotinamide N-methyltransferase (NNMT)

Mouse studies suggest inhibiting NNMT activity in adipose tissue could help treat obesity and type 2 diabetes. Mice with insulin resistance had higher levels of Nnmt mRNA in adipose tissue than mice lacking insulin resistance. In mice, Nnmt-targeting antisense oligonucleotides protected against high-fat diet-induced diabetes by increasing energy expenditure compared with a nontargeting antisense oligonucleotide. Next steps could include testing NNMT inhibition in additional models of metabolic diseases.

SciBX 7(18); doi:10.1038/scibx.2014.527
Published online May 8, 2014

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Kraus, D. et al. Nature; published online April 9, 2014;
Contact: Barbara B. Kahn, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass.