Thursday, May 8, 2014
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Platelet derived growth factor receptor B (PDGFRB;
Studies in mice and human
samples suggest inhibiting PDGFRB could help prevent pancreatic cancer
metastasis. In mice injected with metastasis-prone pancreatic cancer cells,
shRNA knockdown or pharmacological inhibition of Pdgfrb with crenolanib
decreased metastatic spread compared with no alteration or inhibition. In
human pancreatic ductal adenocarcinoma samples, elevated levels PDGFRB
correlated with poor disease-free survival and decreased time to relapse.
Next steps could include evaluating pharmacological PDGFRB inhibitors in
additional pancreatic cancer models.
Novartis AG markets Gleevec,
tyrosine kinase inhibitor, to treat chronic myelogenous
leukemia (CML), acute lymphoblastic leukemia (ALL) and gastrointestinal
stromal tumors (GISTs).
Pharmaceuticals LLC's crenolanib is in Phase II testing to
treat acute myelogenous leukemia (AML) and Phase I to treat brain cancer.
Published online May 8, 2014
Patent and licensing status
Weissmueller, S. et al.
Cell; published online April 10, 2014;
Contact: Scott W. Lowe, Memorial Sloan Kettering Cancer
New York, N.Y.
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