Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Cancer

Cartilage matrix protein matrilin 1 (MATN-1; CMP)

In vitro, chick embryo and mouse studies suggest MATN-1 could help treat cancer by inhibiting angiogenesis. In vitro, recombinant human MATN-1 inhibited endothelial cell proliferation with an IC50 value of about 75 nM and inhibited endothelial cell migration with an IC50 value of about 10 nM. In a chick embryo-based model of angiogenesis, human MATN-1 decreased neovascularization compared with vehicle. In a mouse model of fracture healing, Matn-1 knockout mice healed faster than wild-type mice. Next steps could include testing MATN-1 in mouse models of cancer.

SciBX 7(18); doi:10.1038/scibx.2014.518
Published online May 8, 2014

Patent and licensing status undisclosed

Foradori, M.J. et al. J. Biol. Chem.; published online April 1, 2014;
doi:10.1074/jbc.M113.529982
Contact: Marsha A. Moses, Boston Children's Hospital, Boston, Mass.
e-mail:

marsha.moses@childrens.harvard.edu