Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Autoimmune disease

Inflammatory bowel disease (IBD)

CD1D; IL-10; signal transducer and activator of transcription 3 (STAT3)

Mouse studies suggest epithelial CD1D could help protect against intestinal inflammation in IBD. In a mouse model of chemical-induced colitis, intestinal epithelial cell-specific knockout of Cd1d increased disease severity and mortality compared with no alteration. In the mice, intestinal epithelial Cd1d protected against intestinal inflammation through the activation of Stat3 and Stat3-dependent transcription of the anti-inflammatory cytokine Il-10 and also reinforced expression of Cd1d itself. Next steps could include developing a strategy to selectively upregulate intestinal epithelial CD1D signaling.

SciBX 7(18); doi:10.1038/scibx.2014.515
Published online May 8, 2014

Patent and licensing status unavailable

Olszak, T. et al. Nature; published online April 6, 2014;
doi:10.1038/nature13150
Contact: Richard S. Blumberg, Harvard Medical School,
Boston, Mass.
e-mail:

rblumberg@partners.org
Contact: Sebastian Zeissig, same affiliation as above
e-mail:

szeissig@1med.uni-kiel.de