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Hepatic disease

Liver disease

Sirtuin 7 (SIRT7)

Mouse studies suggest inhibiting SIRT7 could help treat hepatic steatosis. In mice, Sirt7 knockout decreased high-fat diet-induced hepatic lipid accumulation, hepatic triglyceride levels and cholesterol levels compared with no alteration. In the mice, Sirt7 knockout also attenuated high-fat diet-induced weight gain and improved insulin and glucose tolerance. Next steps include understanding the role of SIRT7 in metabolic tissues beyond the liver and validating it as a therapeutic target.

SciBX 7(17); doi:10.1038/scibx.2014.495
Published online May 1, 2014

Unpatented; licensing status not applicable

Yoshizawa, T. et al. Cell Metab.; published online April 1, 2014;
Contact: Kazuya Yamagata, Kumamoto University, Kumamoto, Japan