Thursday, May 1, 2014
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IL-1 receptor-like 1 (IL1RL1;
Mouse and cell culture
studies suggest inhibiting IL-33 signaling could help treat Gleevec
CML. CD34+ cells from patients with CML had surface expression
of ST2 and greater proliferation in response to IL-33 than CD34+ cells from healthy subjects. IL-33 is an activating
ligand for ST2. In patient-isolated CD34+ cells,
IL-33 blocked the effect of Gleevec on proliferation. Next steps could
include evaluating IL-33 inhibitors in combination with Gleevec in models of
AG markets Gleevec, a BCR-ABL
tyrosine kinase inhibitor, to treat CML, acute
lymphoblastic leukemia (ALL) and gastrointestinal stromal tumors (GISTs).
an anti-IL-33 antibody, is in discovery for various inflammatory conditions.
Published online May 1, 2014
Patent and licensing status
Levescot, A. et al.
Cancer Res.; published online March 27, 2014;
Contact: Andre Herbelin, Institut National de la Santé et de
la Recherche Médicale (INSERM), Poitiers, France
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