Licensing status

Publication and contact information

Autoimmune disease


Calcium calmodulin-dependent protein kinase IV (CAMK4)

Studies in human samples and mice suggest inhibiting CAMK4 could help treat lupus. T helper type 17 (Th17) cells are a subset of IL-17-producing T cells that drive multiple autoimmune diseases including lupus. In multiple mouse models of lupus, Camk4 knockout or inhibition with a small molecule decreased disease severity and the number of
IL-17-producing T cells compared with no alteration or inhibition. In T cells from healthy donors and patients with lupus, siRNA against or pharmacological inhibition of CAMK4 decreased IL-17 production compared with control siRNA or no treatment. Next steps include developing a more specific CAMK4 inhibitor and extending the findings to other autoimmune indications including multiple sclerosis (MS), rheumatoid arthritis (RA), glomerulonephritis and vasculitis.

SciBX 7(17); doi:10.1038/scibx.2014.481
Published online May 1, 2014

Patent application filed by Beth Israel Deaconess Medical Center; available for partnering
Contact: Stanley Mah, Beth Israel Deaconess Medical Center, Boston, Mass.

Koga, T. et al. J. Clin. Invest.; published online March 25, 2014;
Contact: George C. Tsokos, Harvard Medical School, Boston, Mass.
Contact: José C. Crispín, same affiliation as above