Thursday, April 24, 2014
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Patient studies suggest
IL-15 could be useful for treating colorectal cancer. In a cohort of patients
with colorectal cancer, carriers of an IL-15 deletion had lower IL-15
expression and showed lower levels of B and T cell proliferation in the tumor
microenvironment than patients without the deletion. Carriers of the IL-15
deletion also showed increased risk of tumor recurrence and decreased
survival. Next steps include developing mouse models to evaluate the
therapeutic use of IL-15 alone and in combination with checkpoint inhibitors.
Altor BioScience Corp. has ALT-803,
an IL-15-mutant agonist complexed to an Fc fusion protein of IL-15
in Phase I testing to treat melanoma and preclinical development for other
Pharma S.A.S. has CYP0150,
a fusion protein of IL-15 and IL-15RA, in preclinical development for cancer
cancer with IL-15 page 7).
Published online April 24, 2014
Patent application filed
covering gene signature for cancer prognosis and tumor classification that
includes IL-15; available for licensing and partnering
Mlecnik, B. et al. Sci.
Transl. Med.; published online March 19, 2014;
Contact: Jérôme Galon, Institut National de la Santé et de
la Recherche Médicale (INSERM), Paris, France
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