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CD248 endosialin (TEM1)

Mouse studies suggest a DNA plasmid encoding a TEM1-tetanus toxoid (TT) fusion peptide could be used as a cancer vaccine. TEM1 is overexpressed in the vasculature and stroma of many human tumors. In multiple mouse xenograft models of human cancer, vaccination with a DNA plasmid encoding Tem1-TT resulted in decreased tumor angiogenesis and growth compared with vaccination using a DNA plasmid encoding Tem1 or TT alone. Next steps include optimizing the vaccine's potency and designing a Phase I trial to evaluate it.

SciBX 7(16); doi:10.1038/scibx.2014.454
Published online April 24, 2014

Patented in the U.S.; patent application filed in the EU; available for licensing

Facciponte, J.G. et al. J. Clin. Invest.; published online March 18, 2014;
Contact: Andrea Facciabene, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa.