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Breast cancer

X-box binding protein 1 (XBP1)

Studies in mice and patient samples suggest inhibiting the XBP1 branch of the unfolded protein response could help treat triple-negative breast cancer (TNBC). In mouse xenograft models of TNBC, shRNA against XBP1 decreased tumor growth, lung metastasis and tumor relapse compared with control shRNA. In two independent TNBC cohorts, an expression signature encompassing 96 XBP1-regulated genes was associated with decreased relapse-free survival. Next steps include establishing preclinical and genetic models to validate the XBP1 pathway as a therapeutic target.

SciBX 7(16); doi:10.1038/scibx.2014.452
Published online April 24, 2014

Patent application filed; unavailable for licensing

Chen, X. et al. Nature; published online March 23, 2014;
Contact: Laurie H. Glimcher, Weill Cornell Medical College,
New York, N.Y.