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Multiple sclerosis (MS)

Fas apoptotic inhibitory molecule 3 (FAIM3; TOSO)

Mouse studies suggest inhibiting the surface receptor TOSO on dendritic cells could help treat MS. In a mouse model of experimental autoimmune encephalomyelitis (EAE), knockout of Toso decreased leukocyte brain infiltration and increased numbers of immune-suppressive T helper cells compared with mice expressing normal Toso levels. In the model, a Toso-Fc fusion protein decreased disease severity and progression in mice that had been allowed to develop EAE prior to treatment. Next steps could include identifying a relevant TOSO ligand and developing a TOSO-directed therapeutic.

SciBX 7(5); doi:10.1038/scibx.2014.149
Published online Feb. 6, 2014

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Brenner, D. et al. Proc. Natl. Acad. Sci. USA; published online Jan. 7, 2014;
Contact: Tak W. Mak, University Health Network, Toronto, Ontario, Canada