Thursday, February 6, 2014
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Cell culture and mouse
studies suggest g-secretase inhibitors could help treat prostate
is the catalytic subunit of g-secretase. In a
human prostate cancer cell line, siRNA knockdown of PS1 decreased production
of the intracellular domain (ICD) of transforming
growth factor-b receptor
compared with no alteration. In various human cancer cell lines and in a
mouse xenograft model of prostate cancer, a g-secretase
inhibitor decreased ICD formation, expression of proinvasive genes, the
number of invasive cells and tumor volume compared with vehicle. Next steps
include testing g-secretase inhibitors in in vivo models of
metastasis and measuring TGFBR1 ICD levels in samples from patients with
At least 10 companies have g-secretase inhibitors in Phase II or earlier testing
to treat Alzheimer's disease (AD) or cancer.
Published online Feb. 6, 2014
Patented; available for
licensing from the Ludwig
Institute for Cancer Research Ltd.
Gudey, S.K. et al. Sci.
Signal.; published online Jan. 7, 2014;
Contact: Marene Landström, Umeå University, Umeå, Sweden
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