Thursday, February 6, 2014
Publication and contact
Cell culture and mouse
studies suggest g-secretase inhibitors could help treat prostate
is the catalytic subunit of g-secretase. In a
human prostate cancer cell line, siRNA knockdown of PS1 decreased production
of the intracellular domain (ICD) of transforming
growth factor-b receptor
compared with no alteration. In various human cancer cell lines and in a
mouse xenograft model of prostate cancer, a g-secretase
inhibitor decreased ICD formation, expression of proinvasive genes, the
number of invasive cells and tumor volume compared with vehicle. Next steps
include testing g-secretase inhibitors in in vivo models of
metastasis and measuring TGFBR1 ICD levels in samples from patients with
At least 10 companies have g-secretase inhibitors in Phase II or earlier testing
to treat Alzheimer's disease (AD) or cancer.
Published online Feb. 6, 2014
Patented; available for
licensing from the Ludwig
Institute for Cancer Research Ltd.
Gudey, S.K. et al. Sci.
Signal.; published online Jan. 7, 2014;
Contact: Marene Landström, Umeå University, Umeå, Sweden
All contents Copyright © 1993-2017 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]