Thursday, January 23, 2014
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Programmed cell death 1 (PDCD1;
PD-1; CD279); hepatitis
A virus cellular receptor 2 (HAVCR2;
suggest combining antibodies against PD-1 and TIM3 could increase patient
response to melanoma vaccines. In peripheral blood mononuclear cells (PBMCs)
taken from patients with metastatic melanoma vaccinated with tumor-associated
antigen 1B (CTAG1B;
peptide, antigen-specific T cell expression of PD-1 and TIM3 was upregulated
in about 73% and 18% of cases. In the PBMCs, the NY-ESO-1 peptide plus both
anti-PD-1 and anti-TIM3 antibodies showed an additive effect in expanding
tumor antigen-specific T cells. Next steps could include testing the antibody
combination with cancer vaccines in patients.
Squibb Co. and Ono
Pharmaceutical Co. Ltd. have the PD-1 antibody nivolumab
in Phase III trials to treat melanoma.
& Co. Inc. has the PD-1 antibody lambrolizumab
in Phase III testing for the indication.
At least four other companies have antibodies against PD-1 in Phase II or
earlier testing to treat cancers.
Published online Jan. 23, 2014
Patent and licensing status
Fourcade, J. et al.
published online Dec. 16, 2013;
Contact: Hassane M. Zarour, University of Pittsburgh School
of Medicine, Pittsburgh, Pa.
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