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Allergy; inflammation

Myeloid differentiation primary response gene 88 (MYD88)

In vitro and mouse studies identified parasitic worm-based compounds that could help treat or prevent inflammation and allergy. In a screen of a drug-like small molecule library based on the structure of phosphorylcholine (PC), an anti-inflammatory product from Acanthocheilonema viteae with poor drug-like properties, a sulfone-containing analog was identified that potently inhibited cytokine production from stimulated macrophages. In a mouse model of collagen-induced arthritis, the analog protected the animals from arthritis by inhibiting Myd88. Next steps include additional studies to further define the compound's mechanism of action.

SciBX 7(1); doi:10.1038/scibx.2014.24
Published online Jan. 9, 2014

Patent application filed; available for licensing

Al-Riyami, L. et al. J. Med. Chem.; published online Nov. 14, 2013;
Contact: William Harnett, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, U.K.