Thursday, January 9, 2014
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Mouse studies suggest
antagonizing IL-12 or using vaccines that limit IL-12 production could help
protect against influenza infection. In mice primed with dendritic cells
presenting an influenza A virus nucleoprotein
(NP) epitope (DC-NP), those
boosted with an NP-expressing vaccinia virus had lower levels of IL-12 and
higher numbers of respiratory, NP-specific memory CD8+ T cells than those boosted with NP-expressing Listeria
monocytogenes (LM-NP). In a mouse model of influenza A virus infection,
adding an anti-IL-12 antibody to the prime and LM-NP boost regimen increased
the number of memory CD8+ T cells and
decreased viral titer compared with adding IgG. Next steps could include
finding additional cytokines that affect the formation of memory CD8+ T cells.
Bristol-Myers Squibb Co.
and Johnson & Johnson
market Stelara ustekinumab, a
human mAb inhibiting IL-12 and IL-23, to treat psoriatic
arthritis and have the drug in Phase III or earlier testing for other
Published online Jan. 9, 2014
Patent and licensing status
Slütter, B. et al.
Immunity; published online Nov. 14, 2013;
Contact: John T. Harty, University of Iowa Carver College of
Iowa City, Iowa
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