Licensing status

Publication and contact information

Autoimmune disease

Autoimmune disease

Inducible T cell kinase (ITK)

Mouse studies suggest inhibiting ITK could help treat autoimmune diseases. In mice, double knockout of Ctla-4 (Cd152) and Itk led to Treg cell accumulation in the lymph nodes and prevented T cell migration, multiorgan autoimmunity and lethality normally caused by Ctla-4 knockout. In female, nonobese, diabetic mice, an ITK inhibitor increased Treg cell accumulation in lymph nodes and decreased T cell migration into islets compared with vehicle and blocked insulitis caused by T cell transfer. Next steps include identifying ITK inhibitors that block T cell migration.

SciBX 7(1); doi:10.1038/scibx.2014.5
Published online Jan. 9, 2014

Patent application filed; unavailable for licensing

Jain, N. et al. Nat. Med.; published online Nov. 24, 2013;
Contact: Joonsoo Kang, University of Massachusetts Medical School, Worcester, Mass.