Licensing status

Publication and contact information

Renal disease

Renal damage

Transient receptor potential cation channel subfamily C member 5 (TRPC5)

In vitro and mouse studies suggest inhibiting the calcium channel TRPC5 could help treat proteinuria. In mice, knockout or inhibition of Trpc5 protected against both lipopolysaccharide (LPS)-induced albuminuria and protamine sulfate-induced kidney filter barrier disruption. In cultured podocytes, a TRPC5 inhibitor prevented protamine sulfate-induced increases in intracellular calcium and cytoskeletal dysregulation associated with breakdown of the filter barrier. Next steps include optimizing a TRPC5 inhibitor for clinical use.

SciBX 6(48); doi:10.1038/scibx.2013.1399
Published online Dec. 19, 2013

Patent status undisclosed; available for licensing

Schaldecker, T. et al. J. Clin. Invest.; published online Nov. 15, 2013;
Contact: Anna Greka, Massachusetts General Hospital, Charlestown, Mass.