Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Neurology

Stroke

Transient receptor potential cation channel subfamily M member 2 (TRPM2); NMDA receptor NR2A subtype (GRIN2A; NR2A); GRIN2B (NR2B)

Mouse studies suggest inhibiting TRPM2 could help prevent ischemic damage to neurons. In a mouse model of stroke, Trpm2 knockout mice showed decreases in the degree of cerebral ischemia compared with unaltered mice. In mouse hippocampal slices and extracts, Trpm2 knockout increased the ratio of GRIN2A to GRIN2B subunits of synaptic NMDARs and increased levels of GRIN2A-mediated prosurvival signaling proteins compared with no alteration. Next steps could include testing TRPM2 inhibitors in preclinical models of stroke.

SciBX 6(48); doi:10.1038/scibx.2013.1398
Published online Dec. 19, 2013

Patent and licensing status unavailable

Alim, I. et al. J. Neurosci.;
published online Oct. 30, 2013;
doi:10.1523/JNEUROSCI.1729-13.2013
Contact: Michael Tymianski, Toronto Western Hospital, Toronto, Ontario, Canada
e-mail:
mike.tymianski@uhn.ca