Thursday, December 19, 2013
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CXC chemokine receptor 4 (CXCR4;
Mouse studies suggest
agonizing CXCR7 or inhibiting CXCR4 could help prevent or treat liver
fibrosis. In mouse models of chronic liver injury, Cxcr7 deficiency in liver
endothelial cells increased hepatic levels of collagen and other profibrotic
factors compared with wild-type Cxcr7 expression. In the models, Cxcr4
deficiency or a Cxcr7 agonist decreased hepatic levels of profibrotic factors
compared with wild-type Cxcr4 expression or vehicle. Planned work includes
further testing of CXCR7 agonists in mouse models of liver injury.
Sanofi markets Mozobil
a synthetic CXCR4 antagonist, to treat multiple myeloma (MM) and non-Hodgkin's
lymphoma (NHL) and has the compound in Phase I testing to treat acute
myelogenous leukemia (AML).
TaiGen Biotechnology Co. Ltd.
has the CXCR4 inhibitor burixafor
in Phase II testing for stem cell transplant in patients with cancer.
Biokine Therapeutics Ltd.
Ltd. have the CXCR4 antagonist BL-8040
in Phase II testing to treat AML and Phase I/II trials to treat cancer (see
act in liver fibrosis, page 9).
Published online Dec. 19, 2013
Patented by Weill
Cornell Medical College; unlicensed
Ding, B.-S. et al.
published online Nov. 20, 2013;
Contact: Shahin Rafii, Weill Cornell Medical College, New
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