Thursday, December 19, 2013
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c-Ros proto-oncogene 1
receptor tyrosine kinase (ROS1)
Mouse and cell culture
studies suggest foretinib
could help treat cancers harboring oncogenic ROS1 fusions and point
mutations. In multiple cancer cell lines and in a mouse cholangiocarcinoma
model expressing an oncogenic Ros1 variant, foretinib suppressed tumor cell
proliferation more efficiently than the anaplastic
lymphoma kinase (ALK)
which also is known to inhibit ROS1. Cancer cells expressing ROS1-mutant
proteins resistant to Xalkori were sensitive to foretinib. Next steps include
evaluating foretinib in a clinical trial in patients with lung cancer
carrying ROS1 fusions, including patients with crizotinib-resistant tumors.
The trial is being designed by GlaxoSmithKline
plc in partnership with the Oregon
Health & Science University.
GSK's foretinib (GSK1363089)
is in Phase I/II testing to treat breast, liver, non-small cell lung and
Pfizer Inc. markets Xalkori
to treat non-small cell lung cancers (NSCLCs) carrying ALK fusions.
Published online Dec. 19, 2013
Patent filed by OHSU;
licensing details available from OHSU
M.A. et al. Proc. Natl. Acad. Sci. USA; published online Nov. 11,
Contact: Brian J. Druker, Oregon Health &
Science University, Portland, Ore.
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